@article{nokey,

title = {Nasoalveolar Molding in Unilateral Cleft Lip and Palate: A Three-Dimensional Analysis},

author = {Yoon Weon Suh and Yong Jong Park and Olivia Yue and Marilia Sayako Yatabe and Heesoo Oh and Lucia Cevidanes and Meghan Hansen and Sophia Dipietro and Jonas Bianchi},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/ocr.70051?getft_integrator=scopus&utm_source=scopus&utm_source=scopus},

doi = {https://doi.org/10.1111/ocr.70051},

year  = {2025},

date = {2025-10-28},

journal = {Orthodontics and Craniofacial Research},

issue = {29},

pages = {83-92},

abstract = {Objectives: This study aimed to three-dimensionally analyze the effects of pre-surgical nasoalveolar molding (NAM) in patients with unilateral cleft lip and palate. Methods: The sample consisted of 66 patients (with pre- and post-NAM casts), collected from three centers. Landmarks and measurements were identified on each cast, and the changes from pre- to post-NAM were recorded and analyzed using a paired t-test. Results: Post-NAM, we observed a mean decrease of 5.18 mm in 3D cleft width, a 1.78 mm decrease in the sagittal cleft gap, a 1.34 mm decrease in the anterior arch width and a 2.27 mm increase in the posterior arch width. There was a greater inward rotation of the greater segment (8.50°) compared to the lesser segment (3.09°), an increase in arch depth (1.74 mm) and internal flexion (9.20°) of the lesser segment. No statistically significant changes in the greater segment's arch depth and internal flexion were observed. The morphological changes between pre- and post-NAM therapy were visualized by the closest-distance color maps and 3D superimposition assessments. Conclusions: This study demonstrated the significant morphological changes induced by pre-surgical nasoalveolar molding (NAM) in patients with unilateral cleft lip and palate through a three-dimensional analysis. There was a notable reduction in cleft width, inward rotation of the greater segment and changes in arch dimensions. },

keywords = {3D analysis, cleft lip and palate, Nasoalveolar, soft tissue morphology},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Deep Learning-Based Three-Dimensional Analysis Reveals Distinct Patterns of Condylar Remodelling After Orthognathic Surgery in Skeletal Class III Patients},

author = {Selene Barone and Lucia Cevidanes and Jonas Bianchi and Joao Roberto Goncalves and Amerigo Giudice},

url = {https://www.scopus.com/pages/publications/85214127594?origin=resultslist&source=sd-apx},

doi = {10.1111/ocr.12895},

year  = {2024},

date = {2024-12-24},

journal = {Orthodontics & Craniofacial Research},

issue = {28},

pages = {441-448},

abstract = {Objective: This retrospective study aimed to evaluate morphometric changes in mandibular condyles of patients with skeletal Class III malocclusion following two-jaw orthognathic surgery planned using virtual surgical planning (VSP) and analyzed with automated three-dimensional (3D) image analysis based on deep-learning techniques. Materials and Methods: Pre-operative (T1) and 12–18 months post-operative (T2) Cone-Beam Computed Tomography (CBCT) scans of 17 patients (mean age: 24.8 ± 3.5 years) were analyzed using 3DSlicer software. Deep-learning algorithms automated CBCT orientation, registration, bone segmentation, and landmark identification. By utilizing voxel-based superimposition of pre- and post-operative CBCT scans and shape correspondence, the overall changes in condylar morphology were assessed, with a focus on bone resorption and apposition at specific regions (superior, lateral and medial poles). The correlation between these modifications and the extent of actual condylar movements post-surgery was investigated. Statistical analysis was conducted with a significance level of α = 0.05. Results: Overall condylar remodeling was minimal, with mean changes of < 1 mm. Small but statistically significant bone resorption occurred at the condylar superior articular surface, while bone apposition was primarily observed at the lateral pole. The bone apposition at the lateral pole and resorption at the superior articular surface were significantly correlated with medial condylar displacement (p < 0.05). Conclusion: The automated 3D analysis revealed distinct patterns of condylar remodeling following orthognathic surgery in skeletal Class III patients, with minimal overall changes but significant regional variations. The correlation between condylar displacements and remodeling patterns highlights the need for precise pre-operative planning to optimize condylar positioning, potentially minimizing harmful remodeling and enhancing stability.},

keywords = {3D analysis, condylar morphology, condylar remodeling, Orthognathic Surgery, skeletal class III},

pubstate = {published},

tppubtype = {article}

}

@article{Bianchi2023m,

title = {Enhancing skeletal stability and Class III correction through active orthodontist engagement in virtual surgical planning: A voxel-based 3-dimensional analysis. },

author = {Barone S and Cevidanes L and Miranda F and Gurgel ML and Anchling L and Hutin N and et al},

url = {https://www.sciencedirect.com/science/article/pii/S0889540623005966?via%3Dihub},

doi = {10.1016/j.ajodo.2023.09.016 },

year  = {2023},

date = {2023-11-27},

journal = {American Journal of Orthodontics & Dentofacial Orthopedics},

volume = {5406},

issue = {23},

abstract = {Introduction

Skeletal stability after bimaxillary surgical correction of Class III malocclusion was investigated through a qualitative and quantitative analysis of the maxilla and the distal and proximal mandibular segments using a 3-dimensional voxel-based superimposition among virtual surgical predictions performed by the orthodontist in close communication with the maxillofacial surgeon and 12-18 months postoperative outcomes.

Methods

A comprehensive secondary data analysis was conducted on deidentified preoperative (1 month before surgery [T1]) and 12-18 months postoperative (midterm [T2]) cone-beam computed tomography scans, along with virtual surgical planning (VSP) data obtained by Dolphin Imaging software. The sample for the study consisted of 17 patients (mean age, 24.8 ± 3.5 years). Using 3D Slicer software, automated tools based on deep-learning approaches were used for cone-beam computed tomography orientation, registration, bone segmentation, and landmark identification. Colormaps were generated for qualitative analysis, whereas linear and angular differences between the planned (T1-VSP) and observed (T1-T2) outcomes were calculated for quantitative assessments. Statistical analysis was conducted with a significance level of α = 0.05.

Results

The midterm surgical outcomes revealed a slight but significantly less maxillary advancement compared with the planned position (mean difference, 1.84 ± 1.50 mm; P = 0.004). The repositioning of the mandibular distal segment was stable, with insignificant differences in linear (T1-VSP, 1.01 ± 3.66 mm; T1-T2, 0.32 ± 4.17 mm) and angular (T1-VSP, 1.53° ± 1.60°; T1-T2, 1.54° ± 1.50°) displacements (P >0.05). The proximal segments exhibited lateral displacement within 1.5° for both the mandibular right and left ramus at T1-VSP and T1-T2 (P >0.05).

Conclusions

The analysis of fully digital planned and surgically repositioned maxilla and mandible revealed excellent precision. In the midterm surgical outcomes of maxillary advancement, a minor deviation from the planned anterior movement was observed.},

keywords = {3D analysis, Class III correction, maxillofacial surgeon, skeletal stability},

pubstate = {published},

tppubtype = {article}

}