@article{nokey,

title = {Orthodontics and bisphosphonates: Risks, limitations, and considerations: A narrative review},

author = {Lorena Wilka and Gabriel Bravo Vallejo and Felicia Miranda and Camila Massaro and Jose Fernando Castanha Henriques and Marcos Roberto de Freitas and Heesoo Oh and Jonas Bianchi},

url = {https://www.sciencedirect.com/science/article/pii/S1073874625000519

},

doi = {https://doi.org/10.1053/j.sodo.2025.06.001},

issn = {1073-8746},

year  = {2025},

date = {2025-09-01},

urldate = {2025-09-01},

journal = {Seminars in Orthodontics},

volume = {31},

issue = {4},

pages = {544-550},

abstract = {The interaction between pharmacological agents and orthodontic treatment is critical in clinical practice. Bisphosphonates have been shown to affect orthodontic tooth movement by altering bone metabolism, slowing bone remodeling, potentially prolonging treatment duration, and increasing the risk of bisphosphonate-related osteonecrosis of the jaw. This narrative review aims to synthesize current literature on the effects of bisphosphonates in orthodontics, highlighting potential complications and outlining key clinical considerations for orthodontists. Although understanding of bisphosphonates has progressed, evidence from human orthodontic studies remains limited and heterogeneous. As such, further high-quality research is necessary to establish definitive clinical guidelines. In the meantime, orthodontic care for patients on bisphosphonate therapy should be approached with caution, emphasizing individualized risk assessment and careful treatment planning to ensure patient safety and optimize outcomes.},

keywords = {Bisphosphonate, Orthodontic anchorage, Orthodontic Tooth Movement, orthodontics},

pubstate = {published},

tppubtype = {article}

}